Dinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration

Dinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration

A family of dinuclear iron (II) compounds with iminopyridine-based ligands displays selective cytotoxic activity against cancer cell lines. All compounds have IC<sub>50</sub> values 2–6 fold lower than that of cisplatin, and 30–90 fold lower than that of carboplatin for the tumor cell li...

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Bibliographic Details
Main Authors: Jessica Castro, Marlon Bravo, Meritxell Albertí, Anaís Marsal, María José Alonso-De Gennaro, Oriol Martínez-Ferraté, Carmen Claver, Piet W. N. M. van Leeuwen, Isabel Romero, Antoni Benito, Maria Vilanova
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
dinuclear iron (II) compounds
iminopyridine ligands
selectivity for tumor cells
cytotoxic mechanism
apoptosis
inhibition of cell migration
Online Access:https://www.mdpi.com/1999-4923/14/12/2801

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https://www.mdpi.com/1999-4923/14/12/2801

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