Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology

Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology

Abstract Preventing tau aggregation is a potential therapeutic strategy in Alzheimer’s disease and other tauopathies. Recently, liquid–liquid phase separation has been found to facilitate the formation of pathogenic tau conformations and fibrillar aggregates, although many aspects of the conformatio...

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Detalles Bibliográficos
Main Authors: Yongqi Huang, Jitao Wen, Lisa-Marie Ramirez, Eymen Gümüşdil, Pravin Pokhrel, Viet H. Man, Haiqiong Ye, Yue Han, Yunfei Liu, Ping Li, Zhengding Su, Junmei Wang, Hanbin Mao, Markus Zweckstetter, Sarah Perrett, Si Wu, Meng Gao
Formato: Artigo
Idioma:English
Publicado: Nature Portfolio 2023-09-01
Series:Nature Communications
Acceso en liña:https://doi.org/10.1038/s41467-023-41241-6

Internet

https://doi.org/10.1038/s41467-023-41241-6

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