Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells

Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells

Background/Aims: Dysregulation of interleukin-6 (IL-6) production in residual renal cells may play a pivotal role in the development of glomerulonephritis (GN). Given that Toll-like receptor 3 (TLR3) signaling has been implicated in the pathogenesis of some forms of GN, we examined activated TLR3-me...

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Bibliographic Details
Main Authors: Qiang Liu, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Hirono, Shogo Kawaguchi, Shojiro Watanabe, Koji Tsugawa, Tomoh Matsumiya, Kazuhiko Seya, Hidemi Yoshida, Hiroshi Tanaka
Format: Article
Language:English
Published: Karger Publishers 2019-02-01
Series:Kidney & Blood Pressure Research
Subjects:
Glomerular endothelial cells
Interleukin-6
Lupus nephritis
Melanoma differentiation associated gene 5
Retinoic acid-inducible gene-I
Toll-like receptor 3
Online Access:https://www.karger.com/Article/FullText/498837

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https://www.karger.com/Article/FullText/498837

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