Discovery of ecnoglutide – A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog

Discovery of ecnoglutide – A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog

Objective: Glucagon-like peptide (GLP)-1 is an incretin hormone that acts after food intake to stimulate insulin production, enhance satiety, and promote weight loss. Here we describe the discovery and characterization of ecnoglutide (XW003), a novel GLP-1 analog. Methods: We engineered a series of...

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Bibliographic Details
Main Authors: Wanjun Guo, Zheng Xu, Haixia Zou, Feng Li, Yao Li, Jing Feng, Zhiyi Zhu, Qing Zheng, Rui Zhu, Bin Wang, Yan Li, Sujuan Hao, Hong Qin, Catherine L. Jones, Eric Adegbite, Libnir Telusca, Martijn Fenaux, Weidong Zhong, Mohammed K. Junaidi, Susan Xu, Hai Pan
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Metabolism
Subjects:
Glucagon-like peptide-1
Ecnoglutide
XW003
Peptide analog
Phase 1
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000960

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http://www.sciencedirect.com/science/article/pii/S2212877823000960

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