Reversal Of Arterial Disease by modulating Magnesium and Phosphate (ROADMAP-study): rationale and design of a randomized controlled trial assessing the effects of magnesium citrate supplementation and phosphate-binding therapy on arterial stiffness in moderate chronic kidney disease

Reversal Of Arterial Disease by modulating Magnesium and Phosphate (ROADMAP-study): rationale and design of a randomized controlled trial assessing the effects of magnesium citrate supplementation and phosphate-binding therapy on arterial stiffness in moderate chronic kidney disease

Abstract Background Arterial stiffness and calcification propensity are associated with high cardiovascular risk and increased mortality in chronic kidney disease (CKD). Both magnesium and phosphate are recognized as modulators of vascular calcification and chronic inflammation, both features of CKD...

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Bibliographic Details
Main Authors: Emma A. Vermeulen, Coby Eelderink, Tiny Hoekstra, Adriana J. van Ballegooijen, Pieter Raijmakers, Joline W. Beulens, Martin H. de Borst, Marc G. Vervloet
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Trials
Subjects:
Magnesium
Phosphate binder
Arterial stiffness
Chronic kidney disease
Calcification
Inflammation
Online Access:https://doi.org/10.1186/s13063-022-06562-9

Internet

https://doi.org/10.1186/s13063-022-06562-9

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