Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03651-9 |