Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

Abstract Background Although polygenic risk score (PRS) has emerged as a promising tool for predicting cancer risk from genome-wide association studies (GWAS), the individual-level accuracy of lung cancer PRS and the extent to which its impact on subsequent clinical applications remains largely unex...

Full description

Bibliographic Details
Main Authors: Xinan Wang, Ziwei Zhang, Yi Ding, Tony Chen, Lorelei Mucci, Demetrios Albanes, Maria Teresa Landi, Neil E. Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D. McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angie Cox, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Rayjean J. Hung, Christopher I. Amos, Xihong Lin, David C. Christiani
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Genome Medicine
Subjects:
Non-small cell lung cancer (NSCLC)
Polygenic risk score (PRSs)
Cancer control
Population science
Genetic epidemiology
Online Access:https://doi.org/10.1186/s13073-024-01298-4

Internet

https://doi.org/10.1186/s13073-024-01298-4

Similar Items