Analysis of HPV Integrations in Mexican Pre-Tumoral Cervical Lesions Reveal Centromere-Enriched Breakpoints and Abundant Unspecific HPV Regions

Analysis of HPV Integrations in Mexican Pre-Tumoral Cervical Lesions Reveal Centromere-Enriched Breakpoints and Abundant Unspecific HPV Regions

Human papillomavirus (HPV) DNA integration is a crucial event in cervical carcinogenesis. However, scarce studies have focused on studying HPV integration (HPVint) in early-stage cervical lesions. Using HPV capture followed by sequencing, we investigated HPVint in pre-tumor cervical lesions. Employi...

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Bibliographic Details
Main Authors: María Lourdes Garza-Rodríguez, Mariel Araceli Oyervides-Muñoz, Antonio Alí Pérez-Maya, Celia Nohemí Sánchez-Domínguez, Anais Berlanga-Garza, Mauro Antonio-Macedo, Lezmes Dionicio Valdés-Chapa, Diego Vidal-Torres, Oscar Vidal-Gutiérrez, Diana Cristina Pérez-Ibave, Víctor Treviño
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
cervical cancer
HPV integration
hot spots
cervical lesions
Online Access:https://www.mdpi.com/1422-0067/22/6/3242

Internet

https://www.mdpi.com/1422-0067/22/6/3242

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