Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1

Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1

Brown adipose tissues (BAT) burn lipids to generate heat through uncoupled respiration, thus representing a powerful target to counteract lipid accumulation and obesity. The tumor suppressor liver kinase b1 (Lkb1) is a key regulator of cellular energy metabolism; and adipocyte-specific knockout of L...

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Bibliographic Details
Main Authors: Yan Xiong, Jessica C. Page, Naagarajan Narayanan, Chao Wang, Zhihao Jia, Feng Yue, Xine Shi, Wen Jin, Keping Hu, Meng Deng, Riyi Shi, Tizhong Shan, Gongshe Yang, Shihuan Kuang
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:EBioMedicine
Subjects:
Brown adipocyte
Liver kinase b1 (serine/threonine kinase 11)
Inflammation
Sciatic nerve
mTOR
Paralysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303705

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http://www.sciencedirect.com/science/article/pii/S2352396417303705

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