Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1

Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1

Brown adipose tissues (BAT) burn lipids to generate heat through uncoupled respiration, thus representing a powerful target to counteract lipid accumulation and obesity. The tumor suppressor liver kinase b1 (Lkb1) is a key regulator of cellular energy metabolism; and adipocyte-specific knockout of L...

Full description

Bibliographic Details
Main Authors:	Yan Xiong, Jessica C. Page, Naagarajan Narayanan, Chao Wang, Zhihao Jia, Feng Yue, Xine Shi, Wen Jin, Keping Hu, Meng Deng, Riyi Shi, Tizhong Shan, Gongshe Yang, Shihuan Kuang
Format:	Article
Language:	English
Published:	Elsevier 2017-10-01
Series:	EBioMedicine
Subjects:	Brown adipocyte Liver kinase b1 (serine/threonine kinase 11) Inflammation Sciatic nerve mTOR Paralysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396417303705

Similar Items

Targeting Protein Kinases and Epigenetic Control as Combinatorial Therapy Options for Advanced Prostate Cancer Treatment
by: Soghra Bagheri, et al.
Published: (2022-02-01)

E. coli Toxin YjjJ (HipH) Is a Ser/Thr Protein Kinase That Impacts Cell Division, Carbon Metabolism, and Ribosome Assembly
by: Fabio Lino Gratani, et al.
Published: (2023-02-01)

Cross-kingdom analyses of transmembrane protein kinases show their functional diversity and distinct origins in protists
by: Zhiyuan Yin, et al.
Published: (2023-01-01)

Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases
by: Baby B, et al.
Published: (2016-09-01)

Kinase Inhibitors that Increase the Sensitivity of Methicillin Resistant Staphylococcus aureus to β-Lactam Antibiotics
by: Jay Vornhagen, et al.
Published: (2015-10-01)

Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor β signaling
by: Pandey Akhilesh, et al.
Published: (2004-01-01)

Critical analysis of graft loss and death in kidney transplant recipients treated with mTOR inhibitors
by: Luis Gustavo Modelli de Andrade, et al.

Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines
by: Laura V Bownes, et al.
Published: (2021-06-01)

Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance <break/>Short Title: Sensitivity Prediction to MAPK Inhibitors in Melanoma
by: Mohamad Krayem, et al.
Published: (2020-02-01)

Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function
by: Mahmoud I. Khalil, et al.
Published: (2023-05-01)

Tuberous sclerosis complex
by: Alexander Jerman, et al.
Published: (2014-05-01)

Characterization of MAGEG2 with testis-specific expression in mice
by: Juri Jeong, et al.
Published: (2017-01-01)

Stress Sensors and Signal Transducers in Cyanobacteria
by: Sergey Kryazhov, et al.
Published: (2010-03-01)

Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver[S]
by: Annika Nerstedt, et al.
Published: (2020-02-01)

Comparative Phenotypic, Proteomic, and Phosphoproteomic Analysis Reveals Different Roles of Serine/Threonine Phosphatase and Kinase in the Growth, Cell Division, and Pathogenicity of <i>Streptococcus suis</i>
by: Qiao Hu, et al.
Published: (2021-11-01)

Expression of the Testis-Specific Serine/Threonine Kinases Suggests Their Role in Spermiogenesis of Bay Scallop Argopecten irradians
by: Xinru Xue, et al.
Published: (2021-03-01)

Everolimus as a therapeutic option in refractory epilepsy in children with tuberous sclerosis: a systematic review
by: Catarina Ester Gomes Menezes, et al.
Published: (2023-04-01)

PEITC: A resounding molecule averts metastasis in breast cancer cells in vitro by regulating PKCδ/Aurora A interplay
by: Souvick Biswas, et al.
Published: (2022-11-01)

The effect and mechanism of rapamycin on the ovarian tissue of rats with PCOS induced by dehydroepiandrosterone
by: Chen Wenli, Wang Huiling, Yang Jun
Published: (2023-03-01)

Light limitation inducing overcompensatory growth of cyanobacteria and function of serine/threonine kinase (STK) genes involved
by: Wei Dai, et al.
Published: (2021-03-01)

Adipocyte-specific DKO of Lkb1 and mTOR protects mice against HFD-induced obesity, but results in insulin resistance
by: Yan Xiong, et al.
Published: (2018-01-01)

High STK40 Expression as an Independent Prognostic Biomarker and Correlated with Immune Infiltrates in Low-Grade Gliomas
by: Pan H, et al.
Published: (2021-10-01)

<i>Drosophila</i> Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Hippo/Warts Signalling Effector Yorkie
by: Eva Louise Steinmetz, et al.
Published: (2021-02-01)

Structure of the Mycobacterium tuberculosis cPknF and conformational changes induced in forkhead-associated regulatory domains
by: Sindy Cabarca, et al.
Published: (2021-01-01)

Discovery of Serine/Threonine-Protein Kinase 4 Inhibitor by Molecular Docking and Molecular Dynamics Studies for Treatment of Diabetes
by: Fatemeh Abdi, et al.
Published: (2022-03-01)

Inhibitors targeting the autophosphorylation of serine/threonine kinase of Streptococcus suis show potent antimicrobial activity
by: Haotian Li, et al.
Published: (2022-09-01)

Cutaneous side-effects during therapy of melanoma by vemurafenib
by: Anna Ankudowicz, et al.
Published: (2015-06-01)

Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy
by: Manli Yu, et al.
Published: (2022-10-01)

Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens
by: Yongqi Yue, et al.
Published: (2022-12-01)

RETRACTED: STK35 Gene Therapy Attenuates Endothelial Dysfunction and Improves Cardiac Function in Diabetes
by: Darukeshwara Joladarashi, et al.
Published: (2022-01-01)

Integrated Analysis of lncRNAs and mRNAs Reveals Complex Gene Network Mediated by lncRNAs and Regulatory Function of <i>MuLRR-RLK-AS</i> in Response to Phytoplasma Infection in Mulberry
by: Zixuan Liu, et al.
Published: (2024-03-01)

Identifying Differences in Molecular Characteristics Relevant for Remodeling of Periodontal Ligament Stem Cells from the Upper and Lower Jaw
by: Hanna Malyaran, et al.
Published: (2024-03-01)

Advancements in the diagnosis and treatment of renal epithelioid angiomyolipoma: A narrative review
by: Jian‐Wei Yang, et al.
Published: (2022-10-01)

The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth
by: Obolbek Turapov, et al.
Published: (2015-01-01)

Review of Defective NADPH Oxidase Activity and Myeloperoxidase Release in Neutrophils From Patients With Cirrhosis
by: Richard Moreau, et al.
Published: (2019-05-01)

Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation
by: Carmen Klein, et al.
Published: (2017-12-01)

Pleiotropic Roles of ChSat4 in Asexual Development, Cell Wall Integrity Maintenance, and Pathogenicity in Colletotrichum higginsianum
by: Ji-Yun Yang, et al.
Published: (2018-10-01)

Disruption of the Serine/Threonine Kinase Akt Gene Affects Ovarian Development and Fecundity in the Cigarette Beetle, Lasioderma serricorne
by: Kang-Kang Xu, et al.
Published: (2021-10-01)

Protein Kinase Serine/Threonine Kinase 24 Positively Regulates Interleukin 17-Induced Inflammation by Promoting IKK Complex Activation
by: Yu Jiang, et al.
Published: (2018-04-01)

Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7
by: Yue Hu, et al.
Published: (2020-11-01)