Combination of IDO inhibitors and platinum(IV) prodrugs reverses low immune responses to enhance cancer chemotherapy and immunotherapy for osteosarcoma

Combination of IDO inhibitors and platinum(IV) prodrugs reverses low immune responses to enhance cancer chemotherapy and immunotherapy for osteosarcoma

In recent years, immune checkpoint blockades (ICBs) have made great progress in the treatment of cancer. However, most ICBs have not yet been observed to be satisfactory in the treatment of osteosarcoma. Herein, we designed composite nanoparticles (NP–Pt-IDOi) from a reactive oxygen species (ROS) se...

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Bibliographic Details
Main Authors: Dongquan Xiang, Xinli Han, Jianxiong Li, Jiabing Zhang, Haihua Xiao, Ting Li, Xuelin Zhao, Hejian Xiong, Meng Xu, Wenzhi Bi
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Materials Today Bio
Subjects:
Indoleamine-(2/3)-dioxygenase inhibitor
Platinum
STING
Osteosarcoma
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423001357

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http://www.sciencedirect.com/science/article/pii/S2590006423001357

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