Liraglutide improves cognition function in streptozotocin-induced diabetic rats by downregulating β-secretase and γ-secretase and alleviating oxidative stress in HT-22 cells

Liraglutide improves cognition function in streptozotocin-induced diabetic rats by downregulating β-secretase and γ-secretase and alleviating oxidative stress in HT-22 cells

Diabetes has been regarded as an independent risk factor for Alzheimer’s disease (AD). Liraglutide could improve cognition in AD mouse models, but its precise mechanism remains unclear. In this study, we used STZ-induced diabetic rats and HT-22 cells to investigate the effects of liraglutide. The MW...

Full description

Bibliographic Details
Main Authors: Lou-yan Ma, Song-fang Liu, Zheng-quan Ma, Ya-gang Guo, Mo Li, Yuan Gao, Yu-ting Wen, Yu Niu, Hai-xia Sui, Bao-shan Li, Ya Li, Ya-li Lv, Yao Huang, Jia-jia Zhai
Format: Article
Language:English
Published: The Japan Endocrine Society 2025-03-01
Series:Endocrine Journal
Subjects:
liraglutide
diabetes
amyloid
bace1
γ-secretase
Online Access:https://www.jstage.jst.go.jp/article/endocrj/72/3/72_EJ23-0723/_html/-char/en

Internet

https://www.jstage.jst.go.jp/article/endocrj/72/3/72_EJ23-0723/_html/-char/en

Similar Items