NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel

NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel

Abstract Background The major dose-limiting toxicity of paclitaxel, one of the most commonly used drugs to treat solid tumor, is painful neuropathy. However, the molecular mechanisms underlying paclitaxel-induced painful neuropathy are largely unclarified. Methods Paw withdrawal threshold was measur...

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Bibliographic Details
Main Authors: Meng Liu, Su-Bo Zhang, Yu-Xuan Luo, Yan-Ling Yang, Xiang-Zhong Zhang, Bo Li, Yan Meng, Yuan-Jie Chen, Rui-Xian Guo, Yuan-Chang Xiong, Wen-Jun Xin, Dai Li
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Paclitaxel
NFATc2
CXCL14
Histone acetylation
Neuropathic pain
Online Access:http://link.springer.com/article/10.1186/s12974-020-01992-1

Internet

http://link.springer.com/article/10.1186/s12974-020-01992-1

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