Expression and role of the immune checkpoint regulator PD-L1 in the tumor-stroma interplay of pancreatic ductal adenocarcinoma

Expression and role of the immune checkpoint regulator PD-L1 in the tumor-stroma interplay of pancreatic ductal adenocarcinoma

IntroductionImmune checkpoint inhibitors (ICI), e.g., targeting programmed cell death protein 1-ligand 1 (PD-L1) or its receptor PD-1, have markedly improved the therapy of many cancers but so far failed in pancreatic ductal adenocarcinoma (PDAC). Macrophages represent one of the most abundant immun...

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Bibliographic Details
Main Authors: Tina Daunke, Silje Beckinger, Sascha Rahn, Sandra Krüger, Steffen Heckl, Heiner Schäfer, Daniela Wesch, Christian Pilarsky, Markus Eckstein, Arndt Hartmann, Christoph Röcken, Anna Maxi Wandmacher, Susanne Sebens
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
pancreatic cancer
immune checkpoint inhibitor
immune evasion
tumor microenvironment
macrophages
3D co-culture
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1157397/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1157397/full

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