Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios

Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios

Abstract Background Determining the impact of somatic mutations requires understanding the functional relationship of genes acquiring mutations; however, it is largely unknown how mutations in functionally related genes influence each other. Methods We employed non-synonymous-to-synonymous or dNdS r...

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Dettagli Bibliografici
Autori principali: Dong-Jin Han, Sunmin Kim, Seo-Young Lee, Youngbeen Moon, Su Jung Kang, Jinseon Yoo, Hye Young Jeong, Hae Jin Cho, Jeong Yang Jeon, Byeong Chang Sim, Jaehoon Kim, Seungho Lee, Ruibin Xi, Tae-Min Kim
Natura: Articolo
Lingua:English
Pubblicazione: BMC 2024-08-01
Serie:Genome Medicine
Soggetti:
Gene pairs
Cancer mutations
dNdS ratios
Evolutionary dependency
Mutation contexts
Genetic dependency
Accesso online:https://doi.org/10.1186/s13073-024-01376-7

Accesso online

https://doi.org/10.1186/s13073-024-01376-7

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