Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model

Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model

Abstract Background Diclofenac etalhyaluronate (DF-HA) is a recently developed analgesic conjugate of diclofenac and hyaluronic acid that has analgesic and anti-inflammatory effects on acute arthritis. In this study, we investigated its analgesic effect on osteoarthritis, using a rat model of monoio...

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Main Authors: Takahito Arai, Miyako Suzuki-Narita, Jun Takeuchi, Ikuko Tajiri, Kazuhide Inage, Yuya Kawarai, Yawara Eguchi, Yasuhiro Shiga, Takashi Hozumi, Geundong Kim, Ryuto Tsuchiya, Takuma Otagiri, Tomohito Mukaihata, Takahisa Hishiya, Noriyasu Toshi, Kohei Okuyama, Soichiro Tokeshi, Takeo Furuya, Satoshi Maki, Yusuke Matsuura, Takane Suzuki, Junichi Nakamura, Shigeo Hagiwara, Seiji Ohtori, Sumihisa Orita
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Musculoskeletal Disorders
Subjects:
Diclofenac etalhyaluronate
Rat monoiodoacetate model
Osteoarthritis
Pain
Online Access:https://doi.org/10.1186/s12891-022-05937-y

Internet

https://doi.org/10.1186/s12891-022-05937-y

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