Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

The histone methyltransferase SET and MYND domain protein 2 (SMYD2) has been implicated in tumorigenesis through methylating histone H3 at lysine36 (H3K36) and some non-histone substrates. Currently, the role of SMYD2 in acute kidney injury (AKI) remains unknown. Here, we investigated the effects of...

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Bibliographic Details
Main Authors: Binbin Cui, Xiying Hou, Mengjun Liu, Qing Li, Chao Yu, Shenglei Zhang, Yi Wang, Jun Wang, Shougang Zhuang, Feng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
acute kidney injury
SMYD2
kidney tubular cells
apoptosis
inflammation
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.829630/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.829630/full

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