Reinforcing properties of Pramipexole in normal and parkinsonian rats

Reinforcing properties of Pramipexole in normal and parkinsonian rats

Striatal D2 and D3 dopamine receptors are involved in mediating the reinforcing properties of natural rewards and drugs. In Parkinson's disease, while D2/3 dopamine agonists alleviate motor symptoms, behavioral addictions and withdrawal syndrome are reported in up to 15% of patients. The origin...

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Bibliographic Details
Main Authors: Michel Engeln, Serge H. Ahmed, Caroline Vouillac, François Tison, Erwan Bezard, Pierre-Olivier Fernagut
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Dopamine agonist
D2/3 agonist
Dopamine replacement therapy
6-OHDA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002926

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http://www.sciencedirect.com/science/article/pii/S0969996112002926

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