Kinetic Study on the Base-Catalyzed Imine-Enamine Tautomerism of a Chiral Biologically Active Isoxazoline Derivative by HPLC on Amylose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase

Kinetic Study on the Base-Catalyzed Imine-Enamine Tautomerism of a Chiral Biologically Active Isoxazoline Derivative by HPLC on Amylose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase

Isoxazoline is a nitrogen- and oxygen-containing five-membered heterocyclic scaffold with diverse biological profiles such as antimicrobial, fungicidal, anticancer, antiviral, analgesic and anti-inflammatory activity. Accordingly, the use of this peculiar structural framework in drug discovery is a...

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Bibliographic Details
Main Authors: Daniele Sadutto, Paolo Guglielmi, Simone Carradori, Daniela Secci, Roberto Cirilli
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
isoxazoline
chiral stationary phase
stereointegrity
imine
enamine
base-catalyzed tautomerization
Online Access:https://www.mdpi.com/1420-3049/28/18/6518

Internet

https://www.mdpi.com/1420-3049/28/18/6518

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