TLR2 is non-redundant in the population and subpopulation responses to Mycobacterium tuberculosis in macrophages and in vivo

TLR2 is non-redundant in the population and subpopulation responses to Mycobacterium tuberculosis in macrophages and in vivo

ABSTRACT Tuberculosis (TB), caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is a global health threat. Targeting host pathways that modulate protective or harmful components of inflammation has been proposed as a therapeutic strategy that could aid sterilization or mitigate TB-a...

Full description

Bibliographic Details
Main Authors: Charul Jani, Sydney L. Solomon, Joshua M. Peters, Stephanie C. Pringle, Amelia E. Hinman, Julie Boucau, Bryan D. Bryson, Amy K. Barczak
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mSystems
Subjects:
tuberculosis
mycobacteria
macrophage
single-cell RNAseq
TLR2
innate immunity
Online Access:https://journals.asm.org/doi/10.1128/msystems.00052-23

Internet

https://journals.asm.org/doi/10.1128/msystems.00052-23

Similar Items