Immune landscape of a genetically engineered murine model of glioma compared with human glioma

Immune landscape of a genetically engineered murine model of glioma compared with human glioma

Novel therapeutic strategies targeting glioblastoma (GBM) often fail in the clinic, partly because preclinical models in which hypotheses are being tested do not recapitulate human disease. To address this challenge, we took advantage of our previously developed spontaneous Qk/Trp53/Pten (QPP) tripl...

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Bibliographic Details
Main Authors: Daniel B. Zamler, Takashi Shingu, Laura M. Kahn, Kristin Huntoon, Cynthia Kassab, Martina Ott, Katarzyna Tomczak, Jintan Liu, Yating Li, Ivy Lai, Rocio Zorilla-Veloz, Cassian Yee, Kunal Rai, Betty Y.S. Kim, Stephanie S. Watowich, Amy B. Heimberger, Giulio F. Draetta, Jian Hu
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-06-01
Series:JCI Insight
Subjects:
Neuroscience
Oncology
Online Access:https://doi.org/10.1172/jci.insight.148990

Internet

https://doi.org/10.1172/jci.insight.148990

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