HIV-1 Tat and Heparan Sulfate Proteoglycans Orchestrate the Setup of <i>in Cis</i> and <i>in Trans</i> Cell-Surface Interactions Functional to Lymphocyte Trans-Endothelial Migration

HIV-1 Tat and Heparan Sulfate Proteoglycans Orchestrate the Setup of <i>in Cis</i> and <i>in Trans</i> Cell-Surface Interactions Functional to Lymphocyte Trans-Endothelial Migration

HIV-1 transactivating factor Tat is released by infected cells. Extracellular Tat homodimerizes and engages several receptors, including integrins, vascular endothelial growth factor receptor 2 (VEGFR2) and heparan sulfate proteoglycan (HSPG) syndecan-1 expressed on various cells. By means of experi...

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Bibliographic Details
Main Authors: Chiara Urbinati, Maria Milanesi, Nicola Lauro, Cinzia Bertelli, Guido David, Pasqualina D’Ursi, Marco Rusnati, Paola Chiodelli
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
HIV-1 Tat
heparan sulfate proteoglycans
lymphocyte extravasation
integrins
signal transduction
endothelial cells
Online Access:https://www.mdpi.com/1420-3049/26/24/7488

Internet

https://www.mdpi.com/1420-3049/26/24/7488

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