JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes

JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes

Monocytes are key effectors in autoimmunity-related diseases in the central nervous system (CNS) due to the critical roles of these cells in the production of proinflammatory cytokines, differentiation of T-helper (Th) cells, and antigen presentation. The JAK–STAT signaling is crucial for initiating...

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Bibliographic Details
Main Authors: Shuai Shao, Chengjuan Chen, Gaona Shi, Yu Zhou, Yazi Wei, Lei Wu, Lan Sun, Tiantai Zhang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Monocytes
T-helper cells
Monocyte-derived dendritic cells
GM-CSF
JAK–STAT signaling
JAK inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523002897

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http://www.sciencedirect.com/science/article/pii/S2211383523002897

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