Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking specific biologic pathways that drive cancer progression and metastasis. Using a...

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Bibliographic Details
Main Authors: Nazareno González, Georgina A. Cardama, Patricio Chinestrad, Javier Robles-Valero, Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Xosé R. Bustelo, Pablo Lorenzano Menna, Daniel E. Gomez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
small-molecule
docking
inhibitor
GTPases
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00240/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00240/full

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