FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter

FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter

Abstract Background Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. FOX family protein lays a pivotal role in metabolism. ROS is involved in tumor progression and is associated with the expression of lots of transcription factors. We next...

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Bibliographic Details
Main Authors: Zhuoying Lin, Wenjie Huang, Qin He, Dongxiao Li, Zhihui Wang, Yangyang Feng, Danfei Liu, Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian, Limin Xia
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Forkhead box C1
Cysteine metabolism
Reactive oxygen species
Cystathionine γ-lyase
DNA methylation
Online Access:https://doi.org/10.1186/s13046-021-01829-6

Internet

https://doi.org/10.1186/s13046-021-01829-6

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