Structural insights into the human niacin receptor HCA2-Gi signalling complex

Structural insights into the human niacin receptor HCA2-Gi signalling complex

Hydroxyl-carboxylic acid receptor 2 (HCA2) functions as a high-affinity receptor for nicotinic acid (vitamin B3). Here, authors report the cryo-EM structure of the HCA2-Gi complex with the agonist MK-6892 and inactive state crystal structures of mutation stabilized HCA2, to describe the mechanism of...

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Bibliographic Details
Main Authors: Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F. DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C. Stevens, Wei Peng, Bryan L. Roth, Zihe Rao, Zhi-Jie Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37177-6

Internet

https://doi.org/10.1038/s41467-023-37177-6

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