A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial
Abstract The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simulta...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Trials |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13063-023-07718-x |
| _version_ | 1797397785555763200 |
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| author | Robert K. Mahar Anna McGlothlin Michael Dymock Todd C. Lee Roger J. Lewis Thomas Lumley Jocelyn Mora David J. Price Benjamin R. Saville Tom Snelling Rebecca Turner Steven A. Webb Joshua S. Davis Steven Y. C. Tong Julie A. Marsh on behalf of the SNAP Global Trial Steering Committee |
| author_facet | Robert K. Mahar Anna McGlothlin Michael Dymock Todd C. Lee Roger J. Lewis Thomas Lumley Jocelyn Mora David J. Price Benjamin R. Saville Tom Snelling Rebecca Turner Steven A. Webb Joshua S. Davis Steven Y. C. Tong Julie A. Marsh on behalf of the SNAP Global Trial Steering Committee |
| author_sort | Robert K. Mahar |
| collection | DOAJ |
| description | Abstract The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection. Here, we formalise the trial structure, modelling approach, and decision rules that will be used for the SNAP trial. By summarising the statistical principles governing the design, our hope is that the SNAP trial will serve as an adaptable template that can be used to improve comparative effectiveness research efficiency in other disease areas. Trial registration NCT05137119 . Registered on 30 November 2021. |
| first_indexed | 2024-03-09T01:16:08Z |
| format | Article |
| id | doaj.art-f2f571ebfaca4b29a4b8ece1023e07d1 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-03-09T01:16:08Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-f2f571ebfaca4b29a4b8ece1023e07d12023-12-10T12:30:39ZengBMCTrials1745-62152023-12-0124111510.1186/s13063-023-07718-xA blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trialRobert K. Mahar0Anna McGlothlin1Michael Dymock2Todd C. Lee3Roger J. Lewis4Thomas Lumley5Jocelyn Mora6David J. Price7Benjamin R. Saville8Tom Snelling9Rebecca Turner10Steven A. Webb11Joshua S. Davis12Steven Y. C. Tong13Julie A. Marsh14on behalf of the SNAP Global Trial Steering CommitteeCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of MelbourneBerry Consultants LLCWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids InstituteDivision of Infectious Diseases, Department of Medicine, McGill UniversityBerry Consultants LLCDepartment of Statistics, University of AucklandDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and ImmunityCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of MelbourneBerry Consultants LLCWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids InstituteMedical Research Council Clinical Trials Unit at University College LondonSt John of God HealthcareDepartment of Infectious Diseases, John Hunter HospitalDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and ImmunityWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids InstituteAbstract The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection. Here, we formalise the trial structure, modelling approach, and decision rules that will be used for the SNAP trial. By summarising the statistical principles governing the design, our hope is that the SNAP trial will serve as an adaptable template that can be used to improve comparative effectiveness research efficiency in other disease areas. Trial registration NCT05137119 . Registered on 30 November 2021.https://doi.org/10.1186/s13063-023-07718-xBayesianPlatformStaphylococcus aureusTrialRandomisedAdaptive |
| spellingShingle | Robert K. Mahar Anna McGlothlin Michael Dymock Todd C. Lee Roger J. Lewis Thomas Lumley Jocelyn Mora David J. Price Benjamin R. Saville Tom Snelling Rebecca Turner Steven A. Webb Joshua S. Davis Steven Y. C. Tong Julie A. Marsh on behalf of the SNAP Global Trial Steering Committee A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial Trials Bayesian Platform Staphylococcus aureus Trial Randomised Adaptive |
| title | A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial |
| title_full | A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial |
| title_fullStr | A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial |
| title_full_unstemmed | A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial |
| title_short | A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial |
| title_sort | blueprint for a multi disease multi domain bayesian adaptive platform trial incorporating adult and paediatric subgroups the staphylococcus aureus network adaptive platform trial |
| topic | Bayesian Platform Staphylococcus aureus Trial Randomised Adaptive |
| url | https://doi.org/10.1186/s13063-023-07718-x |
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