Structures and Dynamics of Native-State Transmembrane Protein Targets and Bound Lipids

Structures and Dynamics of Native-State Transmembrane Protein Targets and Bound Lipids

Membrane proteins work within asymmetric bilayers of lipid molecules that are critical for their biological structures, dynamics and interactions. These properties are lost when detergents dislodge lipids, ligands and subunits, but are maintained in native nanodiscs formed using styrene maleic acid...

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Bibliographic Details
Main Authors: Michael Overduin, Catharine Trieber, R. Scott Prosser, Louis-Philippe Picard, Joey G. Sheff
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Membranes
Subjects:
drug discovery
GPCR
ion channel
native nanodisc
phosphoinositide
transmembrane protein
Online Access:https://www.mdpi.com/2077-0375/11/6/451

Internet

https://www.mdpi.com/2077-0375/11/6/451

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