mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism

mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism

Abstract Infections with rabies virus (RABV) and related lyssaviruses are uniformly fatal once virus accesses the central nervous system (CNS) and causes disease signs. Current immunotherapies are thus focused on the early, pre‐symptomatic stage of disease, with the goal of peripheral neutralization...

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Bibliographic Details
Main Authors: Kate E Mastraccio, Celeste Huaman, Si'Ana A Coggins, Caitlyn Clouse, Madeline Rader, Lianying Yan, Pratyusha Mandal, Imran Hussain, Anwar E Ahmed, Trung Ho, Austin Feasley, Bang K Vu, Ina L Smith, Wanda Markotter, Dawn L Weir, Eric D Laing, Christopher C Broder, Brian C Schaefer
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
adaptive immunity
Australian bat lyssavirus
Fc function
monoclonal antibody
rabies
Online Access:https://doi.org/10.15252/emmm.202216394

Internet

https://doi.org/10.15252/emmm.202216394

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