APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients

APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients

Abstract Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer’s and cardiovascular diseases. Although APOE has recently been associated with increased susceptibility to infections of several vi...

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Bibliographic Details
Main Authors: Hongsheng Zhang, Lin Shao, Zhihao Lin, Quan-Xin Long, Huilong Yuan, Lujian Cai, Guangtong Jiang, Xiaoyi Guo, Renzhi Yang, Zepeng Zhang, Bingchang Zhang, Fan Liu, Zhiyong Li, Qilin Ma, Yun-Wu Zhang, Ai-Long Huang, Zhanxiang Wang, Yingjun Zhao, Huaxi Xu
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01118-4

Internet

https://doi.org/10.1038/s41392-022-01118-4

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