PROTON PUMP INHIBITORS DISPLAY ANTITUMOR EFFECTS IN BARRETT’S ADENOCARCINOMA CELLS

PROTON PUMP INHIBITORS DISPLAY ANTITUMOR EFFECTS IN BARRETT’S ADENOCARCINOMA CELLS

Recent evidence has reported that proton pump inhibitors (PPIs) can exert antineoplastic effects through the disruption of pH homeostasis by inhibiting vacuolar ATPase (H+-VATPase), a proton pump overexpressed in several tumor cells, but this aspect has not been deeply investigated in EAC yet. In th...

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Bibliographic Details
Main Authors: Eduardo Chueca, Nadezda Apostolova, Juan Vicente Esplugues, María Asunción García-González, Angel Lanas, Elena Piazuelo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Pharmacology
Subjects:
Proton Pump Inhibitors
Reactive Oxygen Species
Barrett’s esophagus
Esophageal adenocarcinoma
vacuolar ATPase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00452/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00452/full

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