β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology

β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology

Abstract Alzheimer’s disease (AD) is a progressive, late-onset dementia with no effective treatment available. Recent studies suggest that AD pathology is driven by age-related changes in metabolism. Alterations in metabolism, such as placing patients on a ketogenic diet, can alter cognition by an u...

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Bibliographic Details
Main Authors: Daniel C. Shippy, Connor Wilhelm, Patel A. Viharkumar, Thomas J. Raife, Tyler K. Ulland
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Neuroinflammation
β-Hydroxybutyrate
Inflammasome
Metabolism
Microglia
Online Access:http://link.springer.com/article/10.1186/s12974-020-01948-5

Internet

http://link.springer.com/article/10.1186/s12974-020-01948-5

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