Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice

Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice

Abstract Accumulating evidence indicates that the actin regulator cofilin is overactivated in Alzheimer’s Disease (AD), but whether this abnormality contributes to synaptic and cognitive impairments in AD is unclear. In addition, the brain region and cell types involved remain unknown. In this study...

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Bibliographic Details
Main Authors: Haiwang Zhang, Youssif Ben Zablah, An Liu, Dongju Lee, Haorui Zhang, Yanghong Meng, Changxi Zhou, Xingde Liu, Yiming Wang, Zhengping Jia
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Brain
Subjects:
APP/PS1 transgenic mice
LTP
LIMK1
Cofilin
Learning and memory
Online Access:https://doi.org/10.1186/s13041-021-00833-3

Internet

https://doi.org/10.1186/s13041-021-00833-3

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