Prediction of the Effects of Missense Mutations on Human Myeloperoxidase Protein Stability Using In Silico Saturation Mutagenesis

Myeloperoxidase (MPO) is a heme peroxidase with microbicidal properties. MPO plays a role in the host’s innate immunity by producing reactive oxygen species inside the cell against foreign organisms. However, there is little functional evidence linking missense mutations to human diseases. We utiliz...

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Bibliographic Details
Main Authors: Adebiyi Sobitan, William Edwards, Md Shah Jalal, Ayanfeoluwa Kolawole, Hemayet Ullah, Atanu Duttaroy, Jiang Li, Shaolei Teng
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/13/8/1412