The Effect of DREADD Activation of Leptin Receptor Positive Neurons in the Nucleus of the Solitary Tract on Sleep Disordered Breathing

The Effect of DREADD Activation of Leptin Receptor Positive Neurons in the Nucleus of the Solitary Tract on Sleep Disordered Breathing

Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway due to the loss of upper airway muscle tone during sleep. OSA is highly prevalent, especially in obesity. There is no pharmacotherapy for OSA. Previous studies have demonstrated the role of leptin, an adipose-tissue-produced...

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Bibliographic Details
Main Authors: Mateus R. Amorim, Olga Dergacheva, Thomaz Fleury-Curado, Huy Pho, Carla Freire, David Mendelowitz, Luiz G. S. Branco, Vsevolod Y. Polotsky
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
obstructive sleep apnea
chemogenetics
upper airway dysfunction
Online Access:https://www.mdpi.com/1422-0067/22/13/6742

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https://www.mdpi.com/1422-0067/22/13/6742

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