Dopamine transporter knockout rats as the new preclinical model of hyper- and hypo-dopaminergic disorders

Dopamine transporter knockout rats as the new preclinical model of hyper- and hypo-dopaminergic disorders

Rat line lacking the dopamine transporter (DAT-KO rats) was recently developed. Lack of DAT in these mutants manifests behaviorally as spontaneous hyperactivity and cognitive deficits. It has been shown that d-amphetamine and methylphenidate paradoxically calm down these animals. Also, the inhibitio...

Full description

Bibliographic Details
Main Authors: I. Sukhanov, D. Leo, M. A. Tur, I. V. Belozertseva, A. Savchenko, R. R. Gainetdinov
Format: Article
Language:Russian
Published: Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation 2019-12-01
Series:Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева
Subjects:
dopamine, genetically modified animals, rats, preclinical studies, adhd, parkinson’s disease
Online Access:https://www.bekhterevreview.com/jour/article/view/316

Internet

https://www.bekhterevreview.com/jour/article/view/316

Similar Items