Dopamine transporter knockout rats as the new preclinical model of hyper- and hypo-dopaminergic disorders
Rat line lacking the dopamine transporter (DAT-KO rats) was recently developed. Lack of DAT in these mutants manifests behaviorally as spontaneous hyperactivity and cognitive deficits. It has been shown that d-amphetamine and methylphenidate paradoxically calm down these animals. Also, the inhibitio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| Subjects: | |
| Online Access: | https://www.bekhterevreview.com/jour/article/view/316 |
| Summary: | Rat line lacking the dopamine transporter (DAT-KO rats) was recently developed. Lack of DAT in these mutants manifests behaviorally as spontaneous hyperactivity and cognitive deficits. It has been shown that d-amphetamine and methylphenidate paradoxically calm down these animals. Also, the inhibition of dopamine synthesis in DAT-KO rats represents a straightforward approach for developing the model of severe dopamine deficiency exhibiting characteristic akinetic phenotype which can be reversed by treatment with L-DOPA that used in Parkinson’s disease. These results support the usefulness of DAT-KO rats as models of the disorders associated with dopaminergic dysfunction. |
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| ISSN: | 2313-7053 2713-055X |