Deficiency of LMP10 Attenuates Diet-Induced Atherosclerosis by Inhibiting Macrophage Polarization and Inflammation in Apolipoprotein E Deficient Mice

Deficiency of LMP10 Attenuates Diet-Induced Atherosclerosis by Inhibiting Macrophage Polarization and Inflammation in Apolipoprotein E Deficient Mice

Macrophage polarization and inflammation are key factors for the onset and progression of atherosclerosis. The immunoproteasome complex consists of three inducible catalytic subunits (LMP2, LMP10, and LMP7) that play a critical role in the regulation of these risk factors. We recently demonstrated t...

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Bibliographic Details
Main Authors: Jiawei Liao, Xiangbo An, Xiaolei Yang, Qiu-Yue Lin, Shuang Liu, Yunpeng Xie, Jie Bai, Yun-Long Xia, Hui-Hua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
immunoproteasome
LMP10
diet
atherosclerosis
macrophage
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.592048/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.592048/full

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