Geranylgeranylacetone Ameliorates Skin Inflammation by Regulating and Inducing Thioredoxin via the Thioredoxin Redox System

Geranylgeranylacetone Ameliorates Skin Inflammation by Regulating and Inducing Thioredoxin via the Thioredoxin Redox System

Geranylgeranylacetone (GGA) exerts cytoprotective activity against various toxic stressors via the thioredoxin (TRX) redox system; however, its effect on skin inflammation and molecular mechanism on inducing the TRX of GGA is still unknown. We investigated the effects of GGA in a murine irritant con...

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Bibliographic Details
Main Authors: Tiancheng Jin, Yitong You, Wenjie Fan, Junyang Wang, Yuhao Chen, Shujing Li, Siyuan Hong, Yaxuan Wang, Ruijie Cao, Junji Yodoi, Hai Tian
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Antioxidants
Subjects:
geranylgeranylacetone
irritant contact dermatitis
thioredoxin redox system
PI3K/Akt/Nrf2 signaling pathway
anti-inflammatory effect and mechanism
Online Access:https://www.mdpi.com/2076-3921/12/9/1701

Internet

https://www.mdpi.com/2076-3921/12/9/1701

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