Mechanistic and biophysical characterization of polymyxin resistance response regulator PmrA in Acinetobacter baumannii

Mechanistic and biophysical characterization of polymyxin resistance response regulator PmrA in Acinetobacter baumannii

IntroductionAcinetobacter baumannii PmrAB is a crucial two-component regulatory system (TCS) that plays a vital role in conferring resistance to polymyxin. PmrA, a response regulator belonging to the OmpR/PhoB family, is composed of a C-terminal DNA-binding effector domain and an N-terminal receiver...

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Bibliographic Details
Main Authors: Zhenlin Ouyang, Wenbo He, Min Jiao, Qinyue Yu, Yucheng Guo, Moath Refat, Qian Qin, Jiaxin Zhang, Qindong Shi, Fang Zheng, Yurong Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Microbiology
Subjects:
polymyxin resistance
response regulator
Acinetobacter baumannii
PmrA
mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1293990/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1293990/full

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