PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment

PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment

BackgroundInduced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1)-like iTregs. Thus, it is important to distinguis...

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Bibliographic Details
Main Authors: Nidhi Jadon, Sudarvili Shanthalingam, Gregory N. Tew, Lisa M. Minter
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
aplastic anemia (AA)
bone marrow failure (BMF)
protein arginine methyltransferase 5 (PRMT5)
T helper type 1-like induced regulatory T cells (Th1-like iTregs)
interleukin-12 (IL-12)
sirtuin 1 (SIRT1)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1292049/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1292049/full

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