cGMP Analogues with Opposing Actions on CNG Channels Selectively Modulate Rod or Cone Photoreceptor Function

cGMP Analogues with Opposing Actions on CNG Channels Selectively Modulate Rod or Cone Photoreceptor Function

The vertebrate retina harbors rod and cone photoreceptors. Human vision critically depends on cone photoreceptor function. In the phototransduction cascade, cGMP activates distinct rod and cone isoforms of the cyclic nucleotide-gated (CNG) channel. Excessive cGMP levels initiate a pathophysiological...

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Bibliographic Details
Main Authors: Sophie Wucherpfennig, Wadood Haq, Valerie Popp, Sandeep Kesh, Soumyaparna Das, Christian Melle, Andreas Rentsch, Frank Schwede, François Paquet-Durand, Vasilica Nache
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
CNG channels
retinal degeneration
target selectivity
<i>Retinitis pigmentosa</i>
ion channels
cGMP analogues
Online Access:https://www.mdpi.com/1999-4923/14/10/2102

Internet

https://www.mdpi.com/1999-4923/14/10/2102

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