The impact of N-glycans on the immune response of plant-produced SARS-CoV-2 RBD-Fc proteins

The impact of N-glycans on the immune response of plant-produced SARS-CoV-2 RBD-Fc proteins

Plant-based manufacturing has the advantage of post-translational modifications. While plant-specific N-glycans have been associated with allergic reactions, their effect on the specific immune response upon vaccination is not yet understood. In this study, we produced an RBD-Fc subunit vaccine in b...

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Bibliographic Details
Main Authors: Theerakarn Srisangsung, Thareeya Phetphoung, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Christine Joy I. Bulaon, Arunee Thitithanyanont, Vudhiporn Limprasutr, Richard Strasser, Waranyoo Phoolcharoen
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Biotechnology Reports
Subjects:
RBD-Fc
SARS-CoV-2
Nicotiana benthamiana
Glycans
Immune response
Neutralization
Online Access:http://www.sciencedirect.com/science/article/pii/S2215017X24000201

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http://www.sciencedirect.com/science/article/pii/S2215017X24000201

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