Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young).
CEL-MODY is a monogenic form of diabetes with exocrine pancreatic insufficiency caused by mutations in CARBOXYL-ESTER LIPASE (CEL). The pathogenic processes underlying CEL-MODY are poorly understood, and the global knockout mouse model of the CEL gene (CELKO) did not recapitulate the disease. We the...
Auteurs principaux: | , , , , , , , , , , , , |
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Format: | Article |
Langue: | English |
Publié: |
Public Library of Science (PLoS)
2013-01-01
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Collection: | PLoS ONE |
Accès en ligne: | http://europepmc.org/articles/PMC3615023?pdf=render |