Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity

Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity

Here we report a small library of hydrazinocarbonyl-ureido and thioureido benzenesulfonamide derivatives, designed and synthesized as potent and selective human carbonic anhydrase inhibitors (hCAIs). The synthesized compounds were evaluated against isoforms hCA I, II, IX and XII using acetazolamide...

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Bibliographic Details
Main Authors: Davide Moi, Alessandro Deplano, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran, Valentina Onnis
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
benzene sulfonamides
hydrazidoureas
hydrazidothioureaureas
carbonic anhydrase inhibitors
Online Access:https://www.mdpi.com/1420-3049/27/17/5370

Internet

https://www.mdpi.com/1420-3049/27/17/5370

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