The influence of three-dimensional structure on naïve T cell homeostasis and aging

The influence of three-dimensional structure on naïve T cell homeostasis and aging

A breakdown in cellular homeostasis is thought to drive naïve T cell aging, however the link between naïve T cell homeostasis and aging in humans is poorly understood. To better address this, we developed a lymphoid organoid system that maintains resting naïve T cells for more than 2 weeks, in conju...

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Bibliographic Details
Main Authors: Simon Lambert, Wenqiang Cao, Huimin Zhang, Alex Colville, Jie-Yu Liu, Cornelia M. Weyand, Jorg J. Goronzy, Claire E. Gustafson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Aging
Subjects:
naïve T cells
immune age
homeostasis
organoids
secondary lymphoid tissues
alternative splicing
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2022.1045648/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2022.1045648/full

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