The influence of three-dimensional structure on naïve T cell homeostasis and aging
A breakdown in cellular homeostasis is thought to drive naïve T cell aging, however the link between naïve T cell homeostasis and aging in humans is poorly understood. To better address this, we developed a lymphoid organoid system that maintains resting naïve T cells for more than 2 weeks, in conju...
Main Authors: | Simon Lambert, Wenqiang Cao, Huimin Zhang, Alex Colville, Jie-Yu Liu, Cornelia M. Weyand, Jorg J. Goronzy, Claire E. Gustafson |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-11-01
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Series: | Frontiers in Aging |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2022.1045648/full |
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