Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus

Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus

The CD137—CD137 ligand (CD137L) costimulatory system is a critical immune checkpoint with pathophysiological implications in autoimmunity. In this study, we investigated the role of CD137L-mediated costimulation on renal, cutaneous and cerebral manifestations in lupus and the underlying immunologica...

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Bibliographic Details
Main Authors: Anselm Mak, Bhushan Dharmadhikari, Nien Yee Kow, Thomas Paulraj Thamboo, Qianqiao Tang, Lik Wei Wong, Sreedharan Sajikumar, Hiu Yi Wong, Herbert Schwarz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
CD137 ligand
SLE
glomerulonephritis
skin lesions
synaptic plasticity
Th17
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01411/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01411/full

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