MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation

MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation

Heterochromatin is the highly compacted form of chromatin with various condensation levels hallmarked by high DNA methylation. MeCP2 is mostly known as a DNA methylation reader but has also been reported as a heterochromatin organizer. Here, we combine liquid–liquid phase separation (LLPS) analysis...

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Bibliographic Details
Main Authors: Hui Zhang, Hector Romero, Annika Schmidt, Katalina Gagova, Weihua Qin, Bianca Bertulat, Anne Lehmkuhl, Manuela Milden, Malte Eck, Tobias Meckel, Heinrich Leonhardt, M. Cristina Cardoso
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Nucleus
Subjects:
dna methylation
heterochromatin
liquid-liquid phase separation
mecp2
protein–protein interaction
rett syndrome
single molecule tracking
Online Access:http://dx.doi.org/10.1080/19491034.2021.2024691

Internet

http://dx.doi.org/10.1080/19491034.2021.2024691

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