Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons

The Pax6-α-Cre mouse line used in retinal studies actually contains four transgene insertion within gene clusters of olfactory and vomeronasal receptors, leading to expression in not just retinal, but also olfactory and vomeronasal sensory neurons.

Bibliographic Details
Main Authors: Yimeng Fan, Wenyue Chen, Ran Wei, Wei Qiang, Joel D. Pearson, Tao Yu, Rod Bremner, Danian Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03379-9